Natural Approaches for Auto-immune Diseases: Supporting MS Management Through Nutrition

By Dr Luke McPherson (TCM)

Acupuncture, TCM, Crows Nest

Multiple Sclerosis (MS) is a chronic, immune-mediated disease that targets the central nervous system, disrupting communication between the brain and body. While pharmaceutical therapies remain central to disease management, nutrition is increasingly recognised for its potential to support neurological function, reduce inflammation, and improve quality of life. Two promising nutrients gaining attention in this context are oleic acid and vitamin B12.

Understanding MS and Nutritional Support

MS is characterised by immune-driven demyelination—the stripping away of the protective myelin sheath surrounding nerve fibres. This leads to a wide array of symptoms such as fatigue, weakness, numbness, pain, and cognitive changes. While MS has no known cure, modifiable lifestyle factors, including diet, can significantly impact disease progression and symptom severity.

The Role of Oleic Acid in Brain Health

Oleic acid is a monounsaturated fatty acid predominantly found in olive oil, avocados, almonds, and other plant-based fats. It is a major component of the Mediterranean diet, which has been widely studied for its anti-inflammatory and neuroprotective effects (Trapp et al, 1978).

How Oleic Acid Helps MS Patients:

• Modulates Inflammation: MS involves chronic inflammation, and oleic acid has been shown to suppress pro-inflammatory cytokines and promote a balanced immune response.

• Protects Neural Integrity: Oleic acid contributes to the composition of neuronal membranes and supports the regeneration of myelin—the protective sheath compromised in MS.

• Supports Gut-Brain Axis: Emerging research links oleic acid with improved gut microbiota diversity, which may reduce systemic inflammation and influence autoimmunity, a key factor in MS.

  
  

A 2020 study found that MS patients had lower levels of oleic acid in their immune cells, suggesting that supplementation or dietary intake could potentially modulate disease activity.

Vitamin B12: A Key Player in Myelin Repair

Vitamin B12 (cobalamin) is essential for myelin synthesis, DNA repair, and neurological function. Deficiency in B12 can mimic or exacerbate MS symptoms such as fatigue, numbness, and impaired coordination (Hausser et al, 2020; Miller et al. 2005).

How B12 Supports MS Health:

• Myelin Production: B12 is necessary for methylation processes that produce and maintain the myelin sheath.

• Cognitive Support: Low B12 is associated with brain fog and mood disorders, both of which are common in MS patients.

• Reduces Homocysteine: Elevated homocysteine levels, common in B12 deficiency, are neurotoxic and pro-inflammatory.

  
  

Interestingly, some MS patients may not be clinically deficient in B12 but still benefit from high-dose B12 supplementation, especially methylcobalamin, a neurologically active form of the vitamin.

Synergistic Potential: Oleic Acid + B12

While research is still emerging, the combination of oleic acid and vitamin B12 may offer synergistic benefits:

• Anti-inflammatory + Remyelination: Oleic acid can reduce inflammation, while B12 promotes the repair of damaged myelin (Miller et al, 2005)

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• Cell Membrane Fluidity + Neurological Function: Oleic acid supports membrane integrity, aiding the absorption and function of vitamin B12 within cells.

• Metabolic and Mitochondrial Health: Together, they support energy production at the cellular level, potentially reducing fatigue—a hallmark symptom in MS.

  
  

Practical Tips for Incorporation

Here are simple ways MS patients can include these nutrients in their diet:

• Oleic Acid Sources:

  • Extra virgin olive oil (drizzle over vegetables or salads)

  • Avocados

  • Almonds and macadamia nuts

  • Olives and olive tapenade

    
    

• Vitamin B12 Sources:

  • Animal-based foods: eggs, fish, dairy, and red meat

  • Fortified plant milks or cereals (for vegetarians)

  • Supplements: speak to a healthcare provider about methylcobalamin tablets or injections, especially if you have absorption issues

Final Thoughts

Nutrition isn’t a cure, but it can be a powerful ally in managing MS. Both oleic acid and vitamin B12 offer compelling benefits in supporting neurological health, reducing inflammation, and improving quality of life. As always, patients should consult with their neurologist, acupuncturist, or healthcare team before beginning any supplementation regimen, as dosage may vary from individual to individual.

References

Hauser, J., Sultan, S., Rytz, A., Steiner, P., & Schneider, N. (2020). A blend containing docosahexaenoic acid, arachidonic acid, vitamin B12, vitamin B9, iron and sphingomyelin promotes myelination in an in vitro model. Nutritional Neuroscience, 23(12), 931-945.

Miller, A., Korem, M., Almog, R., & Galboiz, Y. (2005). Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Journal of the neurological sciences, 233(1-2), 93-97.

Trapp, B. D., & Bernsohn, J. (1978). Essential fatty acid deficiency and CNS myelin: biochemical and morphological observations. Journal of the neurological sciences, 37(3), 249-266.